BB-12® (Bifidobacterium animalis ssp. lactis, BB-12®)

Примеры научных публикаций, документирующих эффект штамма BB-12®:

Abi-Hanna, A., Moore, N., Yolken, R., Saavedra, J. Long term consumption of infant formulas with live probiotic bacteria: safety and tolerance. 1998. J Pediatr Gastroenterol Nutr, 27 (4): 484. 

Alm, L., Ryd-Kjellen, E., Setterberg, G., Blomquist, L. Effect of a new fermented milk product «CULTURA» on constipation in geriatric patients. 1993. 1st Lactic Acid Bacteria Computer Conference Proceedings. Horizon Scientific Press, Norfolk, England. 

Anderson ADG, McNaught CE, Jain PK, MacFie J. 2004. Randomised clinical trial of synbiotic therapy in elective surgical patients. Gut, 53, 241-245. 

Anderson ADG, McNaught CE, MacFie J, Tring I, Barker P, Mitchell CJ. 2003. Randomized clinical trial of multimodal optimization and standard perioperative surgical care. British Journal of Surgery, 90; 1497-1504. 

Bin-Nun A, Bromiker R, Wilschanski M, Kaplan M, Rudensky B, Caplan M, Hammerman C. 2005. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. The Journal of Pediatrics 147: 192-196. 

Black, F.T. Placebo-contolled double-blind trial of 4 lactobacilli strains (HIP) used as prophylactic agent against traveller’s diarrhea (2 trials). 1996. Report by G. Nirnberger, Bioconsult, GmbH, Austria. 

Black, F.T., Andersen, P.L., Laulund, S. Report from a double-blind placebo-controlled trial with HIP against traveler’s diarrhea with a new dosage regimen. 1995. Internal report. 

Black, F.T., Einarsson, K., Lidbeck, A., Orrhage, K., Nord, C.E. Effect of lactic acid producing bacteria on the human intestinal microflora during ampicillin treatment. 1991. Scand. J. Infect. Dis., 23: 247-254. 

Black, F.T., Laulund, S. A study on the recovery of ingested, encapsulated Lactobacillus acidophilus and Bifidobacteria bifidum from doudenal fluid and faeces. 1988. Chr. Hansen Internal Report. 

Black, F.T., Anderson, P.L., Orskov J., Orskov, F., Gaarslev, K., Laulund, S. Prophylactic efficacy of lactobacilli on traveler’s diarrhea. 1989. Travel Medicine, 333-335. 

Chouraqui JP, Van Egroo LD, Fichot MC. 2004. Acidified milk formula supplemented with bifidobacterium lactis: Impact on infant diarrhea in residential care settings. Journal of Pediatric Gastroenterology and Nutrition 38:288-292. 

Collins JK, Clune Y, Meaney K, o’Donoghue M, Klinder A, Roller M, Karlsson P, Bennett M, O’Riordan M, Dunne C, O’Sullivan G, Rafter J, Watzl B, Rechkemmer G, Pool-Zobel BL. 2005. The influence of synbiotic consumption on cancer risk biomarkers in previously resected colon cancer subjects. Abstracts / Journal of Biotechnology 118S1: S1-1189. 

Fukushima, Y., Kawata, Y., Hara, H., Terada, A., Mitsuoka, T. Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children. 1998. International Journal of Food Microbiology, 42: 39-44. 

Gatt M, Anderson ADG, Reddy BS, Hayward-Sampson P, tring IC, MacFie J. 2005. Randomized clinical trial of multimodal optimization of surgical care in patients undergoing major colonic resection. British Journal of Surgery, 92, 1354-1362. 

Isolauri, E., Arvola, T., Sutas, Y., Moilanen, E., Salminen, S. Probiotics in the management of atopic eczema. 2000. Clinical and Experimental Allergy, 30: 1604-1610. 

Jain PK, McNaught CE, Anderson ADG, MacFie J, Mitchell CJ. 2004. Influence of synbiotic containing Lactobacillus acidophilus La5, Bifidobacterium lactic Bb12, Streptococcus thermophilus, Lactobacillus bulgaricus and oligofructose on gut barrier function and sepsis in critically ill patients: a randomised controlled trial. Clinical Nutrition 23; 467-475. 

Kankaanpää, PE, Yang, B, Kallio, HP, Isolauri, E, Salminen, SJ. Influence of probiotic supplemented infant formula on composition of plasma lipids in atopic infants. 2002. Journal of Nutritional Biochemistry. 13: 364-369. 

Kankaanpaa, P., Sutas, Y., Salminen, S., Isolauri, E. Results on clinical demonstraion of probiotics on children. Presented at Functional Food Research in Europe, Third Workshop, PROBDEMO, Finland, October 1-2, 1998. 

Kirjavainen, PV, Arvola, T, Salminen, SJ, Isolauri, E. Aberrant composition of gut microbiota of allergic infants: a target of bifidobacterial therapy at weaning? 2002. Gut, 51: 51-55. 

Laake K.O., Bjørneklett A., Aamodt G., Aabakken L., Jacobsen, M., Bakka, A., Vatn, M.H. 2005. Outcome of four weeks intervention with probiotics on symptoms and endoscopic appearance after surgical reconstruction with a J-configurated ileal-pouch-anal-anastomosis in ulcerative colitis. Scandinavian Journal of Gastroenterology (40) 43-51. 

Laake, K.O., P.D. Line, K. Grzyb, G. Aamodt, L. Aabakken, A. Røset, A.B. Hvinden, A. Bakka, J. Eide, A. Bjørneklett, M.H. Vatn. 2004. Assessment of mucosal inflammation and blood flow in response to four weeks intervention with probiotics in patients operated with a J-configurated Ileal-Pouch-Anal-Anastomosis (IPAA). Scand. J. Gastroenterol. (12) 1228-1235. 

Laake KO, Line PD, Aabakken L, Løtveit T, Bakka A, Eide J, Røseth A, Grzyb K, Bjørneklett A, Vatn MH. 2003. Assessment of Mucosal inflammation and circulation in response to probiotics in patients operated with ileal pouch anal anastomosis for ulcerative colitis. Scand J Gastroenterol.: 4; 409-414. 

Laake, K.O., Bjorneklett, A., Bakka, A., Midtvedt, T., Norin, K.E., Eide, T.J., Jacobsen, M.B., Lingaas, E., Axelsen, A.K., Lotveit, T., Vatn, M.H. Influence of fermented milk on clinical state, fecal bacterial counts and biochemical characteristics in patients with ileal- pouch- anal-anastomosis. 1999. Microbial Ecology in Health and Disease, 11: 211-217. 

Langhendries, J.P., Detry, J., Van Hees, J., Lamboray, J.M., Darimont, J., Mozin, M. J., Secretin, M.C., Senterre, J. Effect of a fermented infant formula containing viable bifidobacteria on the fecal flora composition and pH of healthy full-term infants. 1995. Journal of Pediatric Gastroenterology and Nutrition, 21: 177-181. 

Larsen CN, Nielsen S, Kæstel P, Brockmann E, Bennedsen M, Christensen HR, Eskesen DC, Jacobsen BL, Michaelsen KF. 2006. Dose-response study of probiotic bacteria Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus paracasei subsp. paracasei CRL-341 in healthy young adults. European Journal of Clinical Nutrition 60 (11): p. 1284-1293. 

Matsumoto M. and Benno Y. Consumption of Bifidobacterium lactis LKM512 yogurt reduces gut mutagenicity by increasing gut polyamine contents in healthy adult subjects. Mutation Research 2004. 568; 147-153. 

Matsumoto M., H. Ohishi, Y. Benno. 2001. Impact of LKM512 yoghurt on improvement of intestinal environment of the elderly. FEMS Immunology and Medical Microbiology, 31, 181-186. 

Matsumoto, M., T. Tadenuma, K. Nakamure, H. Kume, T. Imai, R. Kihara, M. Watanabe and Y. Benno. 2000. Effect of Bifidobacterium lactis LKM 512 yoghurt on fecal microflora in middle to old aged persons.Microbial Ecology in Health and Disease, 12, 77-80. 

Mohan R, Koebnick C, Schildt J, Schmidt S, Mueller M, Possner M, Radke M, Blaut M. 2006. Effects of Bifidobacterium lactis BB12 supplementation on intestinal microbiota of preterm infants: a double-blind placebo controlled randomized study. J. Clin. Microbiol. E-pub. 

Nord, C.E., Lidbeck, A., Orrhange, K., Sjostedt, S. Oral supplementation with lactic acid bacteria during intake of clindamycin. 1997. Clinical Microbiology and Infection, 3 (1): 124-132. 

Nopchinda S, Varavithya W, Phuapradit P, Sangchai R, Suthutvoravut U, Chantraruksa V, Haschke F. 2002. Effect of Bifidobacterium Bb12 with or without Streptococcus thermophilus supplemented formula on nutritional status. J Med Assoc Thai; 85 (suppl 4) 1225-1231 

Obradovic, D., Curic, M., Ivanovic, M., Trbojevic, B., Djordjevic, M. 1996. Probiotic function of the fermented milk Jogurt Plus. FEMS Conference (Fifthe Symposium on Lactic Acid Bacteria), Holland, Sept. 8-12. 

Phuapradit P, W Varavithya, K Vathanophas, R Sangchai, A Podhipak, U Suthutvoravut, S Nopchinda, V Chantraruksa, F Haschke. 1999. reduction of rotavirus infection in children receiving bifidobacteria-supplemented formula. J. Med. Assoc. Thai. 82, 43-48. 

Rautava S, Arvilommi H, Isolauri E. 2006. Specific probiotics in enhancing maturation of IgA responses in formula-fed infants. Pediatric Research 60(2): 222-225. 

Reddy BS, MacFie J, Gatt M, Larsen CN, Jensen SS, Leser TD. Randomized clinical trial of effect of synbiotics, neomycin and mechanical bowel preparation on intestinal barrier function in patients undergoing colectomy. Br J Surgery 2007;94:In press 

Saavedra JM, Abi-Hanna A, Moore N, Yolken, RH. 2004. Long-term consumption of infant formulas containing live probiotic bacteria: tolerance and safety, Am J Clin Nutr 79: 261-267. 

Saavedra, J., Abi-Hanna, A., Moore, N., Yolken, R. Effect of long term consumption of infant formulas with bifidobacteria and S. thermophilus on stool patterns and diaper rash in infants. 1998. J Pediatr Gastroenterol Nutr, 27 (4): 483. 

Saavedra, J.M., Bauman, N.A., Oung, I., Perman, J.A., Yolken, R.H. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhea and shedding of rotavirus. 1994. The Lancet, 344: 1046-1049. 

Sagen, O.B. Treatment of functional disturbance in the intestine by administration of lactic acid bacteria. 1989. Internal report. 

Schiffrin, E.J., Brassart, D., Servin, A.L., Rochat, F., Donnet-Hughes, A. Immune modulation of blood leucocytes in humans by lactic acid bacteria: criteria for strain selection. 1997. Am J Clin Nutr 66: 515S-520S. 

Schiffrin, E.J., Rochat, F., Link-Amster, H., Aeschlimann, J.M., Donnet-Hughes, A. Immunomodulation of human blood cells following the ingestion of lactic acid bacteria. 1995. Journal of Dairy Science, 78: 491-497. 

Sheu BY, Cheng H-C, Kao A-W, Wang S-T, Yang Y-J, Yang H-B, Wu J-J. 2006. Pretreatment with Lactobacillus- and Bifidobacterium-containing yogurt can improve the efficacy of Quadruple therapy in eradicating residual Helicobacter pylori infection after failed triple therapy. Am J Clin Nutr 83: 864-9. 

Sullivan Å, Barkholt L, Nord CE. 2003. Lactobacillus acidophilus, Bifidobacterium lactis and Lactobacillus F19 prevent antibiotic- associated ecological disturbances of Bacteroides fragilis in the intestine. Journal of Antimicrobial Chemotherapy, 52, 308-311. 

Sheu BS, J Wu, CY Lo, HW Wu, JH Chen, YS Lin & MD Lin. 2002. Impact of supplement with Lactobacillus- and Bifidobacterium-containing yoghurt on triple therapy for Helicobacter pylori eradication. Aliment. Pharmacol. Ther. 16, 1669-1675. 

Virta, P., Otterström, K., Niemi, L., Wieser-Aho, M.-T., Lähteenmäki, A.-L., Leppänen, T. The effect of a preparation containing freeze-dried lactic acid bacteria on lactose intolerance. 1993. External report 

Wang KY, Li SN, Liu CS, Perng DS, Su YC, Wu DC, Jan CM, Lai CH, Wang TN, Wang WM. 2004. Effects of ingesting Lactobacillus- and Bifidobacterium-containing yoghurt in subjects with colonized Helicobacter pylori. Am. J. Clin. Nutr. 80; 737-41. 

Weizman Z, Alsheikh A. 2006. Safety and Tolerance of a Probiotic formula in early infancy comparing two probiotic agents: A pilot study. J Am Coll Nutr. 25(5):415-9. 

Wildt S, Munck LK, Vinter-Jensen L, Hansen BF, Nordgaard-Lassen I, Christensen S, Avnstroem S, Rasmussen SN, Rumessen J. 2006. Probiotic treatment of collagenous colitis: A randomized, double-blind, placebo-controlled trial with L. acidophilus and Bifidobacterium animalis subsp. lactis. Inflamm Bowel Dis 12 (5): 395-401.